Abstract Neuroendocrine prostate cancer is an aggressive variant of prostate cancer that ds durga hand soap may arise de novo or develop from pre-existing prostate adenocarcinoma as a mechanism of treatment resistance.The combined loss of tumor suppressors RB1, TP53, and PTEN are frequent in NEPC but also present in a subset of prostate adenocarcinomas.Most clinical and preclinical studies support a trans-differentiation process, whereby NEPC arises clonally from a prostate adenocarcinoma precursor during the course of treatment resistance.Here we highlight a case of NEPC with significant intra-patient heterogeneity observed across metastases.
We further demonstrate how single-cell genomic analysis of circulating tumor cells combined with a phenotypic evaluation of cellular diversity can be considered as a window into tumor heterogeneity in click here patients with advanced prostate cancer.